1. Kimura T, Pydi SP, Wang L, Haspula D, Cui Y, Lu H, König GM, Kostenis E, Steinberg GR, Gavrilova O & Wess J. 2022. Adipocyte Gq signaling is a regulator of glucose and lipid homeostasis in mice. Nature Communications.13. 1652. DOI:

  2. Barella LF, Pydi SP, Zhu L, Wess J. 2022. b-Arrestins as regulators of key metabolic processes. Arrestins: Structure and Function in Vision and Beyond. 69

  3. Fujimori N, Kimura T, Tanaka N, Yamazaki T, Okumura T, Kobayashi H, Wakabayashi S, Yamashita Y, Sugiura A, Pham J, Pydi SP, Sano K, Joshita S, Umemura T. 2022. 2-Step PLT16-AST44 method: simplified liver fibrosis detection system in patients with non-alcoholic fatty liver disease. Hepatol Res.1–12. DOI:

  4. Pydi SP, Barella LF, Zhu L, Meister J, Rossi M, Wess J. 2021. β-Arrestins as Important Regulators of Glucose and Energy Homeostasis. Annual Review of Physiology. DOI:

  5. Barella LF, Rossi M, Pydi SP, Meister J, Jain S, Cui Y, Gavrilova O, Fulgenzi G, Tessarollo L & Wess J. 2021. β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity. Nature Communications. 12 : 3385. DOI: 10.1038/s41467-021-23656-1

  6. Jain S, Pydi SP, Jung YH, Scortichini M, Kesner EL, Karcz TP, Cook DN, Gavrilova O, Wess J & Jacobson KA. 2021. Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis. JCI Insight 6 (10). DOI: 10.1172/jci.insight.146577

  7. Barella LF, Jain S, Kimura T & Pydi SP*. 2021. Metabolic role of G protein-coupled receptor signaling in obesity and type 2 diabetes. The FEBS Journal. 288 (8), 2622-2644. DOI: 10.1111/febs.15800

  8. Kimura T, Tanaka N, Fujimori N, Yamazaki N, Katsuyama T, Iwashita Y, Pham J, Joshita S, Pydi SP, & Umemura T. 2021. Serum thrombospondin 2 is a predictor of hepatocyte ballooning, NAFLD activity score and fibrosis in patients with NAFLD. Liver International. 41 (3), 505-514. DOI: 10.1111/liv.14776

  9. Meister J, Wang L, Pydi SP, & Wess J. 2021. Chemogenetic Approaches to Identify Metabolically Important GPCR Signaling Pathways: Therapeutic Implications. Journal of Neurochemistry. DOI: 10.1111/jnc.15314

  10. Pydi SP#, Barella LF#, Meister J, & Wess J. 2020. Key Metabolic Functions of β-Arrestins: Studies with Novel Mouse Models. Trends in Endocrinology & Metabolism. 32 (2), 118-129. DOI: 10.1016/j.tem.2020.11.008

  11. Pydi SP*, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Cui Y, Gavrilova O, & Wess J. 2020. β-arrestin-1 Suppresses Myogenic Reprograming of Brown Fat to Maintain Euglycemia. Science Advances. 6, eaba1733. DOI: 10.1126/sciadv.aba1733

  12. Pydi SP, Cui Z, He Z, Barella LF, Cui Y, Oberlin DJ, Egritag HE, Urs N, Gavrilova O, Schwartz GJ, Buettner C, Williams KW, & Wess J. 2020. Beneficial Metabolic Role of b-Arrestin-1 Expressed by AgRP Neurons. Science Advances. 6, eaaz1341. DOI: 10.1126/sciadv.aaz1341

  13. Jain S, Pydi SP, Toti KS, Robaye B, Idzko M, Gavrilova O, Wess J, & Jacobson KA. 2020. Lack of Adipocyte Purinergic P2Y6 Receptor Regulates Whole Body Glucose Homeostasis. Proceedings of the National Academy of Sciences. 117 (48) 30763-30774. DOI: 10.1101/2020.04.03.023234

  14. Wang L, Pydi SP, Cui Y, Zhu L, Barella LF, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C & Wess J. 2020. Adipocyte Gi Signaling is Essential for the Maintenance of Whole-Body Glucose Homeostasis and Insulin Sensitivity. Nature Communications. 11 (1): 2995. DOI: 10.1038/s41467-020-16756-x

  15. Kimura T#, Pydi SP#, Pham J, & Tanaka N. 2020. Metabolic functions of G protein-coupled receptors in hepatocytes-potential applications for diabetes and NAFLD. Biomolecules. 10 (10). 1445. DOI: 10.3390/biom10101445

  16. Wang L, Zhu L, Meister J, Bone D, Pydi SP, Rossi M, & Wess J. 2020. Use of DREADD Technology to Identify Novel Targets for Anti-Diabetic Drugs. Annual Review of Pharmacology and Toxicology. 61, 421-40. DOI: 10.1146/annurev-pharmtox-030220-121042

  17. Pydi SP, Jain S, Tung W, Cui, Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, & Wess J. 2019. Adipocyte β-arrestin-2 is Essential for Maintaining Whole Body Glucose and Energy Homeostasis. Nature Communications. 10 (1): 2936. DOI:

  18. Wang L, Pydi SP, Cui Y, Zhu L, Meister J, Gavrilova O, Berdeaux R, Fortin JP, Bence KK, Vernochet C & Wess J. 2019. Selective Activation of Gs Signaling in Adipocytes Causes Striking Metabolic Improvement in Mice. Molecular Metabolism. S2212-8778 (19), 30457-0. DOI: 10.1016/j.molmet.2019.06.018

  19. Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, & Wess J. 2017. Hepatic Gi Signaling Regulates Whole Body Glucose Homeostasis. The Journal of clinical investigation. 128 (2), 746-759. DOI: 10.1172/jci94505

  20. Bhagirath AY, Pydi SP, Li Y, Lin C, Kong W, Chelikani P, & Duan K. 2017. Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in Pseudomonas aeruginosa. ACS Infectious Diseases. 3 (2), 162-175. DOI:

  21. Pydi SP, Jafurulla M, Wai L, Bhullar R, Chelikani P, & Chattopadhyay A. 2016. Cholesterol Modulates Bitter Taste Receptor Function. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1858 (9), 2081-2087. DOI: 10.1016/j.bbamem.2016.06.005

  22. Pydi SP, Jaggupilli A, Nelson K, Bhullar RP, Loewen M, & Chelikani P. 2014. Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4. Biochemistry 54 (16), 2622-2631. DOI: 10.1021/acs.biochem.5b00265

  23. Pydi SP, Bilakanti R, Sobotkiewicz T, Bhullar R, & Chelikani P. 2014. Amino Acid Derivatives can Act as Bitter Taste Receptor (T2Rs) Blockers. Journal of Biological Chemistry. 289 (36), 25054-25066. DOI: 10.1074/jbc.M114.576975

  24. Pydi SP, Bhullar RP, & Chelikani P. 2014. Constitutive Activity of Bitter Taste Receptors. Advances in Pharmacology. 70, 303-26. DOI: 10.1016/B978-0-12-417197-8.00010-9

  25. Kumar M, Pydi SP, Sharma S, Singh TP, & Kaur P. 2014. Identification of a High Affinity Selective Inhibitor of Polo-like Kinase 1 for Cancer Chemotherapy by Computational Approach. Journal of Molecular Graphics and Modelling. 51, 104-12. DOI: 10.1016/j.jmgm.2014.04.014

  26. Upadhyaya J, Singh N, Sikarwar AS, Chakraborty R, Pydi SP, Bhullar RP, Dakshinamurti S, & Chelikani P. 2014. Dextromethorphan Mediated Bitter Taste Receptor Activation in the Pulmonary Circuit Causes Vasoconstriction. PLoS One. 9 (10), e110373. DOI: 10.1371/journal.pone.0110373

  27. Pydi SP, Upadhyaya J, Singh N, Bhullar RP, & Chelikani P. 2013. The Third Intracellular Loop Plays a Critical Role in Bitter Taste Receptor Activation. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1838 (1PB), 231-236. DOI: 10.1016/j.bbamem.2013.08.009

  28. Pydi SP, Chakraborty R, Bhullar RP, & Chelikani P. 2013. Role of Rhodopsin N-terminus in Structure and Function of Rhodopsin-Bitter Taste Receptor Chimeras. Biochemical and Biophysical Research Communications. 4;430 (1), 179-82. DOI:

  29. Chakraborty R, Pydi SP, Gleim S, Bhullar RP, Dakshinamurti S, Hwa J, & Chelikani P. 2013. New Insights into Structural Determinants for Prostanoid TP and IP Receptor-G Protein Coupling. Molecular and Cellular Biology. 33 (2):184-93. DOI: 10.1128/MCB.00725-12

  30. Pydi SP, Bhullar RP, & Chelikani P. 2012. Constitutively Active Mutant Gives Novel Insights into the Mechanism of Bitter Taste Receptor Activation. Journal of Neurochemistry. 122 (3), 537-44. DOI: 10.1111/j.1471-4159.2012.07808.x

  31. Pydi SP, Upadhyaya J, Singh N, Bhullar RP, & Chelikani P. 2012. Recent Advances in Structure and Function Studies on Human Bitter Taste Receptors. Current Protein and Peptide Science. 13 (6), 501-8. DOI : 10.2174/138920312803582942

  32. Chakraborty R, Pydi SP, Gleim S, Dakshinamurti S, Hwa J, & Chelikani P. 2012. Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4. PLoS One 7 (1): e29996. DOI: 10.1371/journal.pone.0029996

  33. Singh N, Pydi SP, Upadhyaya J, & Chelikani P. 2011. Structural Basis of Activation of Bitter Taste Receptor T2R1 and Comparison with Class A G protein-coupled Receptors (GPCRs). Journal of Biological Chemistry. 286 (41), 36032-36041. DOI: 10.1074/jbc.M111.246983

  34. Upadhyaya J, Pydi SP, Singh N, Aluko RE, & Chelikani P. 2010. Bitter Taste Receptor T2R1 is activated by Dipeptides and Tripeptides. Biochemical and Biophysical Research Communications. 398 (2), 331-335. DOI: 10.1016/j.bbrc.2010.06.097

# Equal Contribution

*Corresponding Author